Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.11.05 | Calcium, Vitamin D and Bone (1) | ECE2015

Determination of reference values for serum total 1,25-dihydroxyvitamin D3 using an extensively validated 2D ID-UPLC–MS/MS method

Dirks Niek , Martens Frans , Vanderschueren Dirk , Billen Jaak , Ackermans Mariette , Endert Erik , Blankenstein Marinus , Heijboer Annemieke

1,25-dihydroxyvitamin D3, the hormonally active metabolite of vitamin D3, tightly controls calcium blood levels. An increase of 1,25-dihydroxyvitamin D3 leads to an increase in calcium concentration with calcium originating from various resources, including bone tissue. To assess a patientÂ’s vitamin D status the precursor metabolite 25-hydroxyvitamin D3 is determined. However, measurement of 1,25-dihydroxyvitamin D is required w...

ea0099rc6.1 | Rapid Communications 6: Thyroid | Part I | ECE2024

Age-specific reference intervals for TSH and FT4 to optimize diagnosis of thyroid disease

Jansen Heleen , Dirks Niek , Hillebrand Jacquelien , Ten Boekel Edwin , Brinkman Jacoline , Buijs Madelon , Demir Ayse , Dijkstra Ineke , Endenburg Silvia , Engbers Paula , Gootjes Jeannette , Janssen Marcel , Kamphuis Stephan , Kniest-de Jong Wilhelmina , Kruit Adrian , Michielsen Etienne , Wolthuis Albert , van Trotsenburg A.S. Paul , den Heijer Martin , Bruinstroop Eveline , Boelen Anita , Heijboer Annemieke C , den Elzen Wendy

Introduction: Thyroid disorders are generally diagnosed based on thyroid stimulating hormone (TSH) outside the reference interval (RI), and subsequent free thyroxine (FT4) concentrations. Most laboratories do not provide age-specific RIs for TSH and FT4 beyond childhood, although it is known that TSH concentrations vary with age which may be important to take into account. Therefore, we aimed to establish age-specific RIs for TSH and FT4 throughout life using an indirect metho...